Year: 2026 | Month: January-March | Volume: 11 | Issue: 1 | Pages: 236-241
DOI: https://doi.org/10.52403/ijshr.20260124
Serum High Sensitive CRP Levels in Patients with Type 2 Diabetes Mellitus: A Case-Control Study
S. Prasannabalaji1, Dhanalakshmi Murugan2
1Assistant Professor, Department of Biochemistry, Government Medical College & Hospital Cuddalore, Chidambaram
2Junior resident, Department of General Medicine, Shri Muthukumaran Medical college Hospital and Research Institute, Kanchipuram
Corresponding Author: Dr. S. Prasannabalaji
ABSTRACT
Background: Type 2 diabetes mellitus (T2DM) is associated with chronic low-grade inflammation, which may contribute to disease pathogenesis and progression. High-sensitive C-reactive protein (hs-CRP) is an established inflammatory biomarker that may be elevated in T2DM patients.
Objective: To evaluate and compare serum hs-CRP levels in patients with Type 2 diabetes mellitus and healthy controls.
Methods: This case-control study included 50 T2DM patients (cases) and 50 age and sex-matched healthy individuals (controls). Patients with Type 1 diabetes, known diabetic complications, hypertension, and other lifestyle diseases were excluded. Serum hs-CRP levels were measured using immunoturbidimetric assay. Data were analyzed using independent t-test and chi-square test. A p-value <0.05 was considered statistically significant.
Results: The mean age of cases was 52.4±8.6 years and controls was 51.8±8.2 years. There were 28 males (56%) and 22 females (44%) in each group. The mean serum hs-CRP level in T2DM patients was 4.82±2.14 mg/L, significantly higher than controls (1.68±0.92 mg/L) with p<0.001. Elevated hs-CRP levels (>3 mg/L) were found in 72% of cases compared to 12% of controls (p<0.001).
Conclusion: Serum hs-CRP levels are significantly elevated in Type 2 diabetes mellitus patients compared to healthy controls, suggesting the presence of chronic subclinical inflammation in T2DM. Hs-CRP may serve as a useful biomarker for assessing inflammatory status in diabetic patients.
Keywords: High-sensitive C-reactive protein, Type 2 diabetes mellitus, inflammation, case-control study, biomarker