Review Article
Year: 2023 | Month: April-June | Volume: 8 | Issue: 2 | Pages: 124-130
DOI: https://doi.org/10.52403/ijshr.20230216
A Review Article of Corticotrophin-Releasing Hormone and Preterm Birth: A Placental Clock
Ervina Pratiwi1, Boy Tarigan Sanjaya2
1Faculty of Medicine, University of HKBP Nommensen Medan-Indonesia
2Faculty of Medicine, University of Methodist Medan-Indonesia
Corresponding Author: Ervina Pratiwi
ABSTRACT
Preterm Birth is one of the main causes of infant mortality and morbidity worldwide. An estimated 15 million preterm births are birthed each year. Preterm Birth is not a single disease but a complex syndrome. The placenta's production of Corticotrophin-Releasing Hormone (CRH) is one theory for Preterm Birth. The peptide hormone CRH, which levels rise exponentially during pregnancy, has been linked to preterm Birth due to its endocrine, autocrine, and paracrine functions. It has been suggested that CRH functions as a component of the placental clock, with preterm Birth occurring when the placental clock is activated too early. In this review article, we will discuss Preterm Birth and the role of CRH in Preterm Birth.
Keywords: Preterm Birth, Corticotrophin-Releasing Hormone (CRH), Placental clock